Shed CNTNAP2 ectodomain is detectable in CSF and regulates ...
Martin-de-Saavedra et al. report that the neuronal sheddome is detectable in human cerebrospinal fluid and is enriched in neurodevelopmental disorder risk factors. Among them is the CNTNAP2 ectodomain. Its synaptic shedding is increased by neuronal activity. CNTNAP2-ecto binds and activates PMCA Ca2+ extrusion pumps and thereby decreases …